In-vitro diffusion study of ibuprofen--cyclodextrin inclusion complex nanogel

The inclusion complex is one way to enhance active substance solubility, affecting medicine dissolution and penetration. formed by utilizing b-cyclodextrin as the host of compounds. Ibuprofen (2-(4-isobutyl-phenyl)propionate) a propionate acid derivative classified in class II Biopharmaceutic Classification System, which has low dissolutions high permeability. This study aims develop nanogel containing ibuprofen-β-cyclodextrin with ratio 1:1, 1:2 2:1; compare in-vitro diffusion profile pure ibuprofen gel. was prepared using coprecipitation method three molar comparison 1:2, 2:1. performed gel-based viscolam, comparing formulas concentration each gel tested experiment 1%. particle size characterization resulted having nanoparticle (510 nm). characteristic indicates that could cumulative release amount compared relatively smaller (156 Pure powder measured be 763 nm 957 nm, respectively. ibuprofen-b-cyclodextrin 2:1 demonstrated an increase 740.3 µg.cm -2 . Meanwhile, had 294.74 at exhibited